Authors: Zubyk HL, Wright GD.
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.00773-21.
PMID: 34001507.
Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2 →
Authors: Sychantha D, Rotondo CM, Tehrani KHME, Martin NI, Wright GD.
Reference: J Biol Chem.
DOI: 10.1016/j.jbc.2021.100918.
PMID: PMC8319579.
Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics →
Authors: Benoit YD, Mitchell RR, Wang W, Orlando L, Boyd AL, Tanasijevic B, Aslostovar L, Shapovalova Z, Doyle M, Bergin CJ, Vojnits K, Casado FL, Di Lu J, Porras DP, García-Rodriguez JL, Russell J, Zouggar A, Masibag AN, Caba C, Koteva K, Kinthada LK, Patel JS, Andres SN, Magolan J, Collins TJ, Wright GD, Bhatia M.
Reference: Cell Chem Biol.
DOI: doi: 10.1016/j.chembiol.2021.04.014.
PMID: 33979648.
The Enzymes of the Rifamycin Antibiotic Resistome →
Authors: Surette MD, Spanogiannopoulos P, Wright GD.
Reference: Accounts of Chemical Research
DOI: 10.1021/acs.accounts.1c00048
PMID: 33877820.
A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent →
Authors: Yarlagadda V, Rao VN, Kaur M, Guitor AK, Wright GD.
Reference: ACS Infect Dis.
DOI: doi: 10.1021/acsinfecdis.1c00040.
PMID: 33826296.
Ancient Antibiotics, Ancient Resistance →
Authors: Waglechner N, Culp EJ, Wright GD.
Reference: EcoSal Plus.
DOI: doi: 10.1128/ecosalplus.ESP-0027-2020.
PMID: 33734062.
The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents →
Authors: Hobson C, Chan AN, Wright GD.
Reference: Chem Rev.
DOI: doi: 10.1021/acs.chemrev.0c01214.
PMID: 33606500.
ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin →
Authors: Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD.
Reference: mBio
DOI: 10.1128/mBio.02705-20
PMID: 33563840
Identifying novel β-lactamase substrate activity through in silico prediction of antimicrobial resistance →
Authors: Tsang KK, Maguire F, Zubyk HL, Chou S, Edalatmand A, Wright GD, Beiko RG, McArthur AG.
Reference: Microb Genom
DOI: 10.1099/mgen.0.000500
PMID: 33416461
Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity →
Authors: Yarlagadda V, Medina R, Johnson TA, Koteva KP, Cox G, Thaker MN, Wright GD.
Reference: ACS Infect Dis.
DOI: 10.1021/acsinfecdis.0c00467
PMID: 33164482
GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery →
Authors: Xu M, Wang W, Waglechner N, Culp EJ, Guitor AK, Wright GD.
Reference: Nat Commun.
DOI: 10.1038/s41467-020-19138-5
PMID: 33067466
Membrane interactions of non-membrane targeting antibiotics: The case of aminoglycosides, macrolides, and fluoroquinolones →
Authors: Khondker A, Bider RC, Passos-Gastaldo I, Wright GD, Rheinstädter MC.
Reference: Biochim Biophys Acta Biomembr.
DOI: 0.1016/j.bbamem.2020.183448
PMID: 32828850
COVID-19 and Antimicrobial Resistance: Parallel and Interacting Health Emergencies →
Authors: Nieuwlaat R, Mbuagbaw L, Mertz D, Burrows L, Bowdish DME, Moja L, Wright GD, Schünemann HJ.
Reference: Clin Infect Dis.
DOI: 110.1093/cid/ciaa773
PMID: 32544232
Antibiotic Resistance by Enzymatic Modification of Antibiotic Targets →
Authors: Schaenzer AJ and Wright GD
Reference: Trends Mol Med.
DOI: 10.1016/j.molmed.2020.05.001
PMID: 32493628
Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics →
Authors: Yarlagadda V, Medina R and Wright GD
Reference: Sci Rep.
DOI: 10.1038/s41598-020-64756-0
PMID: 32424122
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development →
Authors: Jacques S, van der Sloot AM, Huard CC, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD and Tyers M.
Reference: Genetics
DOI: 10.1534/genetics.119.302851
PMID: 32094149
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling →
Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner →
Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375
CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database →
Authors: Alcock BP, Raphenya AR, Lau TTY, Tsang KK, Bouchard M, Edalatmand A, Huynh W, Nguyen AV, Cheng AA, Liu S, Min SY, Miroshnichenko A, Tran HK, Werfalli RE, Nasir JA, Oloni M, Speicher DJ, Florescu A, Singh B, Faltyn M, Hernandez-Koutoucheva A, Sharma AN, Bordeleau E, Pawlowski AC, Zubyk HL, Dooley D, Griffiths E, Maguire F, Winsor GL, Beiko RG, Brinkman FSL, Hsiao WWL, Domselaar GV, McArthur AG.
Reference: Nucleic Acids Res.
DOI: 10.1093/nar/gkz935
PMID: 31665441
Capturing the Resistome: a Targeted Capture Method To Reveal Antibiotic Resistance Determinants in Metagenomes →
Authors: Guitor AK, Raphenya AR, Klunk J, Kuch M, Alcock B, Surette MG, McArthur AG, Poinar HN and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01324-19
PMID: 31611361