Authors: George, M., Wright, G.D.
DOI: 10.1016/j.mib.2024.102576
PMID: 39742555
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database →
Authors: Brian P Alcock, William Huynh, Romeo Chalil, Keaton W Smith, Amogelang R Raphenya, Mateusz A Wlodarski, Arman Edalatmand, Aaron Petkau, Sohaib A Syed, Kara K Tsang, Sheridan J C Baker, Mugdha Dave, Madeline C McCarthy, Karyn M Mukiri, Jalees A Nasir, Bahar Golbon, Hamna Imtiaz, Xingjian Jiang, Komal Kaur, Megan Kwong, Zi Cheng Liang, Keyu C Niu, Prabakar Shan, Jasmine Y J Yang, Kristen L Gray, Gemma R Hoad, Baofeng Jia, Timsy Bhando, Lindsey A Carfrae, Maya A Farha, Shawn French, Rodion Gordzevich, Kenneth Rachwalski, Megan M Tu, Emily Bordeleau, Damion Dooley, Emma Griffiths, Haley L Zubyk, Eric D Brown, Finlay Maguire, Robert G Beiko, William W L Hsiao, Fiona S L Brinkman, Gary Van Domselaar, Andrew G McArthur.
Reference: Nucleic Acids Research
DOI: 10.1093/nar/gkac920
PMID: 36263822
Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease →
Authors: Guitor A.K, Katyukhina A, Mokomane M, Lechiile K, Goldfarb D.M, Wright G.D, McArthur A.G, Pernica J.M.
Reference: The Journal of Infectious Diseases
DOI: 10.1093/infdis/jiae049
PMID: 39052715
Antibiotic resistance: A key microbial survival mechanism that threatens public health →
Authors: Abbas A*, Barkhouse A*, Hackenberger D, Wright G.D.
Reference: Cell Host & Microbe
DOI: 10.1016/j.chom.2024.05.015
PMID: 38870900
Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes →
Authors: Sychantha D, Chen X, Koteva K, Prehna G, Wright G.D.
Reference: Nature Communications
DOI: 10.1038/s41467-024-48232-1
PMID: 38740750
Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory →
Authors: Cook M.A, Pallant D, Ejim L, Sutherland A.D, Wang X, Johnson J.W, McCusker S, Chen X, George A, Chou S, Koteva K, Wang W, Hobson C, Hackenberger D, Waglechner N, Ejim O, Campbell T, Medina R, MacNeil L.T, Wright G.D.
Reference: Journal of Industrial Microbiology and Biotechnology
DOI: 10.1093/jimb/kuad042
PMID: 38052426
Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus →
Authors: Kalinka Koteva, Min Xu, Wenliang Wang, Aline A. Fiebig-Comyn, Michael A. Cook, Brian K. Coombes, and Gerard D. Wright
Reference: The Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.3c00633
PMID: 37315221
Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance →
Authors: Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD.
Reference: Nature Chemical Biology
DOI: 10.1038/s41589-023-01483-3
PMID: 37973888
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. →
Authors: Pawlowski AC, Stogios PJ, Koteva K, Skarina T, Evdokimova E, Savchenko A, Wright GD
Reference: Nature Communications 2018 ;9(1):112
DOI: 10.1038/s41467-017-02680-0.
PMID: 29317655
Transformation of the anticancer drug doxorubicin in the human gut microbiome →
Authors: A Yan, E Culp, J Perry, J Lau, L MacNeil, MG Surette, GD Wright
Reference: ACS Infectious Disease (Available online November 21 2017)
DOI: 10.1021/acsinfecdis.7b00166
PMID: 29160065
Inhibitors of metallo-β-lactamases. →
Authors: CM Rotondo and GD Wright
Reference: Current Opinion in Microbiology 2017 39: 96-105
PMID: 29154026
Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7. →
Authors: Bergstrom A, Katko A, Adkins Z, Hill J, Cheng Z, Burnett M, Yang H, Aitha M, Mehaffey MR, Brodbelt JS, Tehrani KHME, Martin NI, Bonomo RA, Page RC, Tierney DL, Fast W, Wright GD, Crowder MW
Reference: ACS Infectious Disease (Epub)
DOI: 10.1021/acsinfecdis.7b00106
PMID: 29091730
Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites. →
Authors: Gehrke SS, Kumar G, Yokubynas NA, Côté JP, Wang W, French S, MacNair CR, Wright GD, Brown ED.
Reference: ACS Infectious Disease (Epub)
DOI: 10.1021/acsinfecdis.7b00149
PMID: 29069544
Lessons from Environmental Antibiotic Resistome →
Authors: MD Surette and GD Wright
Reference: Annual Review of Microbiology Vol. 71:309-329
PMID: 28657887
Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli. →
Authors: Smith NM, Bulman ZP, Sieron AO, Bulitta JB, Holden PN, Nation RL, Li J, Wright GD, Tsuji BT.
Reference: Journal of Antimicrobial Chemotherapy 2017 Aug 1;72(8):2297-2303
PMID: 28505268
Evolving medicinal chemistry strategies in antibiotic discovery →
Authors: AC Pawlowski, JW Johnson, GD Wright
Reference: Curr Opin Biotechnol. 2016 Apr 23;42:108-117. doi: 10.1016/j.copbio.2016.04.006.
PMID: 27116217
A diverse intrinsic antibiotic resistome from a cave bacterium →
Authors: Pawlowski AC, Wang W, Koteva K, Barton HA, McArthur AG, Wright GD.
Reference: Nat Commun. 2016 Dec 8;7:13803. doi: 10.1038/ncomms13803.
PMID: 27929110
Bacterial proteases, untapped antimicrobial drug targets. →
Authors: E Culp, GD Wright
Reference: Journal of Antibiotics (Tokyo) April; 70(4) 366-377
PMID: 27899793
A Common Platform for Antibiotic Dereplication and Adjuvant Discovery →
Authors: Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 29. pii: S2451-9456(16)30434-2. doi: 10.1016/j.chembiol.2016.11.011.
PMID: 28017602
Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function →
Authors: Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015.
PMID: 27746129