Authors: George, M., Wright, G.D.
DOI: 10.1016/j.mib.2024.102576
PMID: 39742555
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database →
Authors: Brian P Alcock, William Huynh, Romeo Chalil, Keaton W Smith, Amogelang R Raphenya, Mateusz A Wlodarski, Arman Edalatmand, Aaron Petkau, Sohaib A Syed, Kara K Tsang, Sheridan J C Baker, Mugdha Dave, Madeline C McCarthy, Karyn M Mukiri, Jalees A Nasir, Bahar Golbon, Hamna Imtiaz, Xingjian Jiang, Komal Kaur, Megan Kwong, Zi Cheng Liang, Keyu C Niu, Prabakar Shan, Jasmine Y J Yang, Kristen L Gray, Gemma R Hoad, Baofeng Jia, Timsy Bhando, Lindsey A Carfrae, Maya A Farha, Shawn French, Rodion Gordzevich, Kenneth Rachwalski, Megan M Tu, Emily Bordeleau, Damion Dooley, Emma Griffiths, Haley L Zubyk, Eric D Brown, Finlay Maguire, Robert G Beiko, William W L Hsiao, Fiona S L Brinkman, Gary Van Domselaar, Andrew G McArthur.
Reference: Nucleic Acids Research
DOI: 10.1093/nar/gkac920
PMID: 36263822
Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease →
Authors: Guitor A.K, Katyukhina A, Mokomane M, Lechiile K, Goldfarb D.M, Wright G.D, McArthur A.G, Pernica J.M.
Reference: The Journal of Infectious Diseases
DOI: 10.1093/infdis/jiae049
PMID: 39052715
Antibiotic resistance: A key microbial survival mechanism that threatens public health →
Authors: Abbas A*, Barkhouse A*, Hackenberger D, Wright G.D.
Reference: Cell Host & Microbe
DOI: 10.1016/j.chom.2024.05.015
PMID: 38870900
Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes →
Authors: Sychantha D, Chen X, Koteva K, Prehna G, Wright G.D.
Reference: Nature Communications
DOI: 10.1038/s41467-024-48232-1
PMID: 38740750
Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory →
Authors: Cook M.A, Pallant D, Ejim L, Sutherland A.D, Wang X, Johnson J.W, McCusker S, Chen X, George A, Chou S, Koteva K, Wang W, Hobson C, Hackenberger D, Waglechner N, Ejim O, Campbell T, Medina R, MacNeil L.T, Wright G.D.
Reference: Journal of Industrial Microbiology and Biotechnology
DOI: 10.1093/jimb/kuad042
PMID: 38052426
Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus →
Authors: Kalinka Koteva, Min Xu, Wenliang Wang, Aline A. Fiebig-Comyn, Michael A. Cook, Brian K. Coombes, and Gerard D. Wright
Reference: The Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.3c00633
PMID: 37315221
Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance →
Authors: Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD.
Reference: Nature Chemical Biology
DOI: 10.1038/s41589-023-01483-3
PMID: 37973888
Angucyclinones rescue PhLOPSA antibiotic activity by inhibiting Cfr-dependent antibiotic resistance →
Authors: Schaenzer AJ, Hernandez AR, Tsai K, Hobson C, Fujimori DG, Wright GD.
Reference: ASM mBio.
DOI: 10.1128/mbio.01791-23
PMID: 38014974
Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation. →
Authors: Guitor AK, Yousuf EI, Raphenya AR, Hutton EK, Morrison KM, McArthur AG, Wright GD, Stearns JC.
Reference: Microbiome.
DOI: 10.1186/s40168-022-01327-7.
PMID: PMC9414150
The past, present, and future of antibiotics →
Authors: Cook MA, Wright GD.
Reference: Sci Transl Med.
DOI: 10.1126/scitranslmed.abo7793.
PMID: 35947678
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics →
Authors: Surette MD, Waglechner N, Koteva K, Wright GD.
Reference: Mol Cell.
DOI: 10.1016/j.molcel.2022.06.019.
PMID: 35907401
Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics →
Authors: Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, and Gerard D. Wright.
Reference: ACS Central Science
DOI: 10.1021/acscentsci.1c01389.
PMID:
Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family →
Authors: Stogios PJ, Bordeleau E, Xu Z, Skarina T, Evdokimova E, Chou S, Diorio-Toth L, D'Souza AW, Patel S, Dantas G, Wright GD, Savchenko A.
Reference: Commun Biol.
DOI: 10.1038/s42003-022-03219-w.
PMID: 35338238.
ClpP inhibitors are produced by a widespread family of bacterial gene clusters →
Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
DOI: 10.1038/s41564-022-01073-4.
PMID: 35246663.
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A →
Authors: Koteva K, Sychantha D, Rotondo CM, Hobson C, Britten JF, Wright GD.
Reference: ACS Omega.
DOI: 10.1021/acsomega.1c05757.
PMID: 35155911.
Prospects for Antibacterial Discovery and Development →
Authors: Privalsky TM, Soohoo AM, Wang J, Walsh CT, Wright GD, Gordon EM, Gray NS, Khosla C.
Reference: J Am Chem Soc.
DOI: 10.1021/jacs.1c10200.
PMID: 34860516.
Glycopeptide antibiotic discovery in the genomic era →
Authors: Xu M, Wang W, Wright GD.
Reference: Methods Enzymol.
DOI: 10.1016/bs.mie.2021.11.009. .
PMID: 35379441.
Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics →
Authors: Salamaga B, Kong L, Pasquina-Lemonche L, Lafage L, von Und Zur Muhlen M, Gibson JF, Grybchuk D, Tooke AK, Panchal V, Culp EJ, Tatham E, O'Kane ME, Catley TE, Renshaw SA, Wright GD, Plevka P, Bullough PA, Han A, Hobbs JK, Foster SJ.
Reference: Proc Natl Acad Sci U S A
DOI: 10.1073/pnas.2106022118.
PMID: 34716264.
A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity →
Authors: Alder A, Struck NS, Xu M, Johnson JW, Wang W, Pallant D, Cook MA, Rambow J, Lemcke S, Gilberger TW, Wright GD.
Reference: Cell Chem Biol.
DOI: 10.1016/j.chembiol.2021.10.005.
PMID: 34710358.